C13H21No3=238.50. An alkaloid obtained from the Anhalonium Williamsii (nat. ord. Cactacece).

Habitat

Mexico.

Characters

The hydrochloride, which is to be found in the shops, occurs as a colorless, amorphous, intensely bitter powder.

Solubility

Readily in water.

Dose, 1/2 to 1 gr.; .03 to .06 gm. (Hypodermatically.)

Action Of Pellotine

Slight narcosis follows its injection in from ten to fifteen minutes (frogs). The reflexes are somewhat diminished. After twenty to thirty minutes there comes a distinct increase of reflex irritability, followed by spasms, resembling strychnine poisoning. If large doses are administered this condition may pass into one of complete paralysis. The pulse rate is slightly diminished, drowsiness and sleep supervene after its administration to man. The drug is probably excreted by the kidneys.

Therapeutics Of Pellotine

Pellotine has been recently introduced as a hypnotic which, because it is unirritating, can be used hypodermatically. It slows the pulse slightly, induces a feeling of weariness, weight of eyelids and limbs, disinclination to mental and bodily exertion, and a quiet sleep follows. The awakening is easy and usually without untoward symptoms. In full doses, with the patient in an upright position it may give rise to vertigo. It apparently has no effect on the secretions.

B. Cerebral Excitants.