To this group belong those remedies usually classed together under the designation of antispasmodics. They are to a slight degree cardiac stimulants; they increase the cutaneous circulation and promote diaphoresis; they also stimulate the bronchial mucous membrane and favor expectoration. As a result in part of the increased rapidity of the circulation, the functions of the brain become slightly more active, ideas flow more freely, irregular mental excitement and muscular hyperkinesis are moderated, and an orderly feeling of well-being is experienced. These effects are probably in part due to a direct action of these agents on the gray matter of the hemispheres, but our knowledge does not at present permit an exact statement of the nature of this impression. These agents do not in any quantity suspend the functions of the brain, and the temporary increase of activity which they produce is not followed by manifest depression.