The most important of the glandular remedies after the thyroid is the supra-renal. Some favorable reports have been made regarding the utility of preparations of the kidney, in affections of this organ especially, but in respect to well-defined physiological action the suprarenal is much superior. Pellets of the gland, extracts, and its active principle adrenalin, have been employed with much success in suitable cases. The gland substance is prescribed in the form of pellets of three to five grains; the extract is much employed topically in affections of the throat and nasal passages and elsewhere, and the adrenalin hydrochloride is also applied to the conjunctiva and to accessible mucous surfaces in the form of a solution having the strength of 1 to 1,000. Whether applied topically or taken internally, characteristic effects follow, chiefly on the vasomotor system, increasing the energy and lessening the number of the heart beats, raising the arterial tension, and thus diminishing the blood supply to a given area. Applied to the mucous membrane, it contracts the vessels, and the surface appears blanched and bloodless.