A. Eliminated in part by the skin, 13, 79. Erythema of the face, T. Fox, 137, 1/67, 46ft.

B. In general it brings out, after a few hours, an eruption of minute red papules, which are always more numerous in proportion to the deli-cacy and vascularity of the skin, and which gradually are converted into pustules. Some of these have the Battened and umhilicated aspect of the variolous or the tartar emetic eruption, but the greater number are acuminate and rounded.

Many of them are apt to be confluent. They are surrounded by a red areola, and accompanied with a more or leas severe burning pain and itching. The eruption augments for three or four days, and then remains stationary. Somewhat later the pustules break in part and form scabs, and in part wither away If they are numerous and large they become confluent and form thick and extensive crusts. Between the sixth and twelfth days they separate and leave no cicatrices behind them, 10,

When the oil is applied to the skin, of the arm, for instance, at the end of a variable period (half an hour or more), the skin loses its oily aspect (elle se ressuie), the greater portion of the oil having been imbibed by the epidermis. A part of it, however, will be found in the clefts of the epidermis and at the base of the hairs. After a few hours slight itching begins to be felt. Heat and rubbing increases the pruritus, which increases in severity. After three to six hours redness appears. Later this redness is more vivid at certain points and little papules (boutons) appear, most frequently seated at the base of the hairs. The inflammation may cease at this point and the papules gradually subside in twenty-four hours or so without giving rise to pustules; or, a few hours later, the papules become transparent at their points from effusion of serum, and are transformed into vesicles. Still later the serum becomes milky and opaque, and the vesicles in turn become pustules, which enlarge and, as a rule, become umbilicated.

When the pustules are small they are usually found at the base of a hair, which they finally surround.

Three kinds of pustules depending on the degree of inflammatory action are met with: 1. The intra-epidermic pustule, which is small, sharply-defined, and superficial. Its location is between the layers of the stratum corneum, or between the stratum corneum and the stratum Malpighii. On disappearing it leaves no scar. This superficial pustule is sometimes found on top of a deeper-seated one, forming a sort of double-decked pustule. 2. The sub-epidermic pustule, more deeply-seated than the preceding, is located just under the epidermis, and lifts its entire thickness. It is surrounded by an inflammatory roseola, and is tender to the touch, but not otherwise painful. Its contents is creamy and it increases in size for two days, remains stationary during the third, and begins to fade away on the fourth. Union of several adjacent pustules sometimes occurs, forming a compound pustule of variable size. 3. The dermic pustule is the preceding with deeply inflamed base, involving the entire thickness of the skin and the tissues beneath. Its contour is less sharply defined, and it forms a hard and painful elevation, containing sometimes a little blood mixed with the pus, which gives it a darker color. In addition to these lesions a follicular tubercle or pustule sometimes forms. It is slightly elevated, hard, solid, reddish-brown, and not specially tender or painful, and at its pointed summit displays a trace of pus, usually already dried by the time it is observed. It arises from extension of the inflammation into a hair-follicle, following one of the more superficial pustules already described. It usually persists longer than the other lesions, and disappears by absorption in twelve or fifteen days.

The pustules of the second class, after drying, leave a coppery stain, which gradually disappears. Rarely the inflammation is so severe as to result in destruction of a portion of dermic tissue with a resulting cicatrix. Vautherin.*

D. Trichophytosis capitis, Horand, 106, 7: 19; Ladreit de Lacharriere, 117, Aug. 15, '76; Gassicourt, 117, Nov. 15 and 30, '77; (H.G.P.).